Fads3 modulates docosahexaenoic acid in liver and brain
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چکیده
منابع مشابه
Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum.
The loss of docosahexaenoic acid (DHA) from the retina or brain has been associated with a loss in nervous-system function in experimental animals, as well as in human infants fed vegetable oil-based formulas. The reversibility of the loss of DHA and the compensation by an increase in the n-6 docosapentaenoic acid (DPAn-6) was studied in young adult rats. Long-Evans rats were subjected to a ver...
متن کاملPlasma phospholipid-mediated transfer of docosahexaenoic acid from liver to brain phospholipids in type 1 and type 2 diabetic rats.
Docosahexaenoic acid (C22:6ω3) generated in the liver from circulating α-linolenic acid (C18:3ω3) was recently proposed as the source of brain C22:6ω3 when the latter fatty acid is absent from the diet. The present study aims at exploring whether a comparable situation prevails in Types 1 and 2 diabetic rats, even when exposed to a normal diet. The fatty acid profile of liver, plasma and brain ...
متن کاملMaternal docosahexaenoic acid-enriched diet prevents neonatal brain injury.
Hypoxic-ischemic encephalopathy due to neonatal asphyxia is one of the most important causes of delayed neurological development. Prolonged neuronal apoptosis plays an important role in the processes contributing to neuronal degeneration. Docosahexaenoic acid (DHA), a major component of brain membrane phospholipids, prevents neuronal cell apoptosis and plays an important role as an anti-oxidant...
متن کاملRole of Docosahexaenoic Acid Treatment in Improving Liver Histology in Pediatric Nonalcoholic Fatty Liver Disease
INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver-related morbidity and mortality in children. Recently, we have reported the effects of docosahexaenoic acid (DHA), the major dietary long-chain polyunsaturated fatty acids, in children with NAFLD. DHA exerts a potent anti-inflammatory activity through the G protein-coupled receptor (GPR)120. Our a...
متن کاملDocosahexaenoic Acid (DHA)
Handling & Preparation Instructions This purified fatty acid is liquid at room temperature (oil) and not soluble in water. The product is supplied sterile. It can be solubilized in undiluted serum, ethanol or DMSO. The solubility of Docosahexaenoic acid in ethanol is at least 100 mg/ml. Docosahexaenoic acid has a solubility of 1 mg/ml in a solution of 0.15 M Tris-HCL (pH 8.5). We strongly recom...
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ژورنال
عنوان ژورنال: Prostaglandins, Leukotrienes and Essential Fatty Acids
سال: 2017
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2017.07.001